Anest. intenziv. Med. 2024;35(1):19-30 | DOI: 10.36290/aim.2023.079

Advanced bloodless clinical procedures proven in practiceReview Article

Slipac J.
Canadian Medical, s. r. o., Brno

A better understanding of risks associated with allogeneic blood transfusions along with a growing population of patients seeking surgical care without the use of blood transfusion has led to the development of complex clinical strategies, intending to minimize blood loss, conserve autologous blood, enhance hematopoiesis, and augment tolerance of anemia. Advances in surgical technique, current technology, knowledge, and perioperative management significantly contributed to the fact that successful treatment without transfusion is a realistic option but it does require a concerted patient-centered effort from the multidisciplinary team. In this review, we discuss effective bloodless strategies in the setting of perioperative management, acute blood loss, trauma, and postpartum hemorrhage. Additionally, the valuable experience gained from bloodless care has paved the way to develop the concept of Patient Blood Management as a standard care to benefit all patients, and not only those for whom blood is not an option.

Keywords: bloodless clinical strategies, anemia, hemorrhage, Patient Blood Management.

Received: July 25, 2023; Revised: November 28, 2023; Accepted: December 14, 2023; Prepublished online: January 29, 2024; Published: March 28, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Slipac J. Advanced bloodless clinical procedures proven in practice. Anest. intenziv. Med. 2024;35(1):19-30. doi: 10.36290/aim.2023.079.
Download citation

References

  1. Scharman CD, Burger D, Shatzel JJ, Kim E, DeLoughery TG. Treatment of individuals who cannot receive blood products for religious or other reasons. Am J Hematol. 2017 Dec;92(12):1370-1381. doi: 10.1002/ajh.24889. Epub 2017 Sep 29. PMID: 28815690. Go to original source... Go to PubMed...
  2. Resar LM, Wick EC, Almasri TN, Dackiw EA, Ness PM, Frank SM. Bloodless medicine: current strategies and emerging treatment paradigms. Transfusion. 2016 Oct;56(10):2637-2647. doi: 10.1111/trf.13736. Epub 2016 Jul 29. PMID: 27473810. Go to original source... Go to PubMed...
  3. Frank SM, Pippa A, Sherd I, Scott AV, Lo BD, Cruz NC, et al. Methods of Bloodless Care, Clinical Outcomes, and Costs for Adult Patients Who Decline Allogeneic Transfusions. Anesth Analg. 2022 Sep 1;135(3):576-585. doi: 10.1213/ANE.0000000000006114. Epub 2022 Aug 17. PMID: 35977366. Go to original source... Go to PubMed...
  4. World Health Organization Policy Brief - The Urgent Need to Implement Patient Blood Management. December 9, 2021. Available from: https://apps.who.int/iris/bitstream/handle/10665/346655/9789240035744-eng.pdf?sequence=1 & isAllowed=y.
  5. Klein AA, Bailey CR, Charlton A, Lawson C, Nimmo AF, Payne S, et al. Association of Anaesthetists: anaesthesia and peri­‑operative care for Jehovah's Witnesses and patients who refuse blood. Anaesthesia. 2019 Jan;74(1):74-82. doi: 10.1111/anae.14441. Epub 2018 Sep 30. PMID: 30270470. Go to original source... Go to PubMed...
  6. Shander A, Goodnough LT. Management of anemia in patients who decline blood transfusion. Am J Hematol. 2018 Sep;93(9):1183-1191. doi: 10.1002/ajh.25167. Epub 2018 Sep 3. PMID: 30033541. Go to original source... Go to PubMed...
  7. Slipac J. Patient Blood Management - Proč? Praha: Triton; 2020. ISBN 978-80-7553-759-1.
  8. Shander A, Javidroozi M. Blood conservation strategies and the management of perioperative anaemia. Curr Opin Anaesthesiol. 2015 Jun;28(3):356-63. doi: 10.1097/ACO.0000000000000179. PMID: 25827281. Go to original source... Go to PubMed...
  9. Salmen M, Hendriksen S, Gorlin J, LeClaire M, Prekker ME. Oxygen Delivery during Severe Anemia When Blood Transfusion Is Refused on Religious Grounds. Ann Am Thorac Soc. 2017 Jul;14(7):1216-1220. doi: 10.1513/AnnalsATS.201612-1039CC. PMID: 28665709. Go to original source... Go to PubMed...
  10. Johnson­‑Arbor K, Verstraete R. Bloodless Management of the Anemic Patient in the Emergency Department. Ann Emerg Med. 2022 Jan;79(1):48-57. doi: 10.1016/j.annemergmed.2021. 06. 015. Epub 2021 Aug 2. PMID: 34353645. Go to original source...
  11. Lasocki S, Pène F, Ait­‑Oufella H, Aubron C, Ausset S, Buffet P, et al. Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Ann Intensive Care. 2020 Jul 22;10(1):97. doi: 10.1186/s13613-020-00711-6. PMID: 32700082; PMCID: PMC7374293. Go to original source... Go to PubMed...
  12. Crowe EP, DeSimone RA. When blood transfusion is not an option owing to religious beliefs. Ann Blood. 2022;7:22. doi: 10.21037/aob-21-58. Go to original source...
  13. Munoz C, Aletti F, Govender K, Cabrales P, Kistler EB. Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes. Front Med (Lausanne). 2020 Oct 27;7:585638. doi: 10.3389/fmed.2020.585638. PMID: 33195342; PMCID: PMC7652927. Go to original source... Go to PubMed...
  14. Guinn NR, Resar LMS, Frank SM. Perioperative Management of Patients for Whom Transfusion Is Not an Option. Anesthesiology. 2021 Jun 1;134(6):939-948. doi: 10.1097/ALN.0000000000003763. PMID: 33857295. Go to original source... Go to PubMed...
  15. Rozental O, Cushing MM, Shander A, Isbister JP, Lasocki S, Meybohm P, et al. Penny­‑wise and pound­‑foolish: the challenges of preoperative anaemia management. Br J Anaesth. 2023 May 25:S0007-0912(23)00231-3. doi: 10.1016/j.bja.2023. 04. 038. Epub ahead of print. PMID: 37244835. Go to original source...
  16. Kei T, Mistry N, Curley G, Pavenski K, Shehata N, Tanzini RM, et al. Efficacy and safety of erythropoietin and iron therapy to reduce red blood cell transfusion in surgical patients: a systematic review and meta­‑analysis. Can J Anaesth. 2019 Jun;66(6):716-731. English. doi: 10.1007/s12630-019-01351-6. Epub 2019 Mar 28. PMID: 30924000. Go to original source... Go to PubMed...
  17. Cho BC, Serini J, Zorrilla­‑Vaca A, Scott MJ, Gehrie EA, Frank SM, Grant MC. Impact of Preoperative Erythropoietin on Allogeneic Blood Transfusions in Surgical Patients: Results From a Systematic Review and Meta­‑analysis. Anesth Analg. 2019 May;128(5):981-992. doi: 10.1213/ANE.0000000000004005. PMID: 30649068. Go to original source... Go to PubMed...
  18. di Girolamo G, Keller GA, Beider L, González CD, González Bagnes MF, González E, et al. Pharmacokinetic and pharmacodynamic study of three products of epoetin alfa as single subcutaneous dose in healthy volunteers. Fundam Clin Pharmacol. 2023 Jun;37(3):651-662. doi: 10.1111/fcp.12869. Epub 2023 Feb 10. PMID: 36639980. Go to original source... Go to PubMed...
  19. Pasricha SR, Tye­‑Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. Lancet. 2021 Jan 16;397(10270):233-248. doi: 10.1016/S0140-6736(20)32594-0. Epub 2020 Dec 4. PMID: 33285139. Go to original source... Go to PubMed...
  20. Tan GM, Guinn NR, Frank SM, Shander A. Proceedings From the Society for Advancement of Blood Management Annual Meeting 2017: Management Dilemmas of the Surgical Patient­‑When Blood Is Not an Option. Anesth Analg. 2019 Jan;128(1):144-151. doi: 10.1213/ANE.0000000000003478. PMID: 29958216. Go to original source... Go to PubMed...
  21. Shander A, Corwin HL, Meier J, Auerbach M, Bisbe E, Blitz J, et al. Recommendations From the International Consensus Conference on Anemia Management in Surgical Patient s (ICCAMS). Ann Surg. 2023 Apr 1;277(4):581-590. doi: 10.1097/SLA.0000000000005721. Epub 2022 Sep 21. PMID: 36134567; PMCID: PMC9994846. Go to original source... Go to PubMed...
  22. Slipac J. Předoperační anémie: výskyt, příčiny, následky, diagnostika a léčba. Prakt Lék. 2018;98(3):99-103.
  23. Muñoz M, Acheson AG, Auerbach M, Besser M, Habler O, Kehlet H, et al. International consensus statement on the peri­‑operative management of anaemia and iron deficiency. Anaesthesia. 2017 Feb;72(2):233-247. doi: 10.1111/anae.13773. Epub 2016 Dec 20. PMID: 27996086. Go to original source... Go to PubMed...
  24. Stoffel NU, Zeder C, Brittenham GM, Moretti D, Zimmermann MB. Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron­‑deficient anemic women. Haematologica. 2020 May;105(5):1232-1239. doi: 10.3324/haematol.2019.220830. Epub 2019 Aug 14. PMID: 31413088; PMCID: PMC7193469. Go to original source... Go to PubMed...
  25. Gómez­‑Ramírez S, Brilli E, Tarantino G, Girelli D, Muñoz M. Sucrosomial® Iron: An Updated Review of Its Clinical Efficacy for the Treatment of Iron Deficiency. Pharmaceuticals (Basel). 2023 Jun 6;16(6):847. doi: 10.3390/ph16060847. PMID: 37375794; PMCID: PMC10305423. Go to original source... Go to PubMed...
  26. Spahn DR, Muñoz M, Klein AA, Levy JH, Zacharowski K. Patient Blood Management: Effectiveness and Future Potential. Anesthesiology. 2020 Jul;133(1):212-222. doi: 10.1097/ALN.0000000000003198. PMID: 32108683. Go to original source... Go to PubMed...
  27. Spahn DR, Schoenrath F, Spahn GH, Seifert B, Stein P, Theusinger OM, et al. Effect of ultra­‑short­‑term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. Lancet. 2019 Jun 1;393(10187):2201-2212. doi: 10.1016/S0140-6736(18)32555-8. Epub 2019 Apr 26. PMID: 31036337. Go to original source... Go to PubMed...
  28. Kietaibl S, Ahmed A, Afshari A, Albaladejo P, Aldecoa C, Barauskas G, et al. Management of severe peri­‑operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care: Second update 2022. Eur J Anaesthesiol. 2023 Apr 1;40(4):226-304. doi: 10.1097/EJA.0000000000001803. PMID: 36855941. Go to original source... Go to PubMed...
  29. Slipac J. Bezkrevní medicína. 2. aktualizované vydání. Praha: Triton; 2011. ISBN 978-80-7387-465-0.
  30. Patel PA, Fabbro M 2nd. Expanding the Utilization of Acute Normovolemic Hemodilution. J Cardiothorac Vasc Anesth. 2020 Jul;34(7):1761-1762. doi: 10.1053/j.jvca.2020. 03. 030. Epub 2020 Apr 15. PMID: 32359709.5 Go to original source...
  31. Shander A, Brown J, Licker M, Mazer DC, Meier J, Ozawa S, Tibi PR, Van der Linden P, Perelman S. Standards and Best Practice for Acute Normovolemic Hemodilution: Evidence­‑based Consensus Recommendations. J Cardiothorac Vasc Anesth. 2020 Jul;34(7):1755-1760. doi: 10.1053/j.jvca.2020. 01. 019. Epub 2020 Jan 17. PMID: 32127266. Go to original source...
  32. Neef V, Vo L, Herrmann E, Triphaus C, Judd L, Winter A, et al. The association between intraoperative cell salvage and red blood cell transfusion in cardiac surgery - an observational study in a patient blood management centre. Anaesthesiol Intensive Ther. 2021;53(1):1-9. doi: 10.5114/ait.2021.103735. PMID: 33625822; PMCID: PMC10158449. Go to original source... Go to PubMed...
  33. Carroll C, Young F. Intraoperative cell salvage. BJA Educ. 2021 Mar;21(3):95-101. doi: 10.1016/j.bjae.2020. 11. 007. Epub 2021 Jan 22. PMID: 33664978; PMCID: PMC7892352. Go to original source...
  34. Wu WW, Zhang WY, Zhang WH, Yang L, Deng XQ, Ou MC, et al. Survival analysis of intraoperative blood salvage for patients with malignancy disease: A PRISMA­‑compliant systematic review and meta­‑analysis. Medicine (Baltimore). 2019 Jul;98(27):e16040. doi: 10.1097/MD.0000000000016040. PMID: 31277097; PMCID: PMC6635293. Go to original source... Go to PubMed...
  35. Kumar N, Tan JYH, Chen Z, Ravikumar N, Milavec H, Tan JH. Intraoperative cell­‑salvaged autologous blood transfusion is safe in metastatic spine tumour surgery: early outcomes of prospective clinical study. Eur Spine J. 2023 May 16. doi: 10.1007/s00586-023-07768-4. Epub ahead of print. PMID: 37191676. Go to original source... Go to PubMed...
  36. Kulkarni S, Parina R, Henderson R, Derek E, Selby T, Kwon Y, et al. Transfusion­‑free Strategies in Liver and Pancreatic Surgery: A Predictive Model of Blood Conservation for Transfusion Avoidance in Mainstream Populations. Ann Surg. 2023 Mar 1;277(3):469-474. doi: 10.1097/SLA.0000000000005757. Epub 2022 Nov 17. PMID: 36538643. Go to original source... Go to PubMed...
  37. Aijtink VJ, Rutten VC, Meijer BEM, de Jong R, Isaac JL, Polak WG, et al. Safety of Intraoperative Blood Salvage During Liver Transplantation in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta­‑analysis. Ann Surg. 2022 Aug 1;276(2):239-245. doi: 10.1097/SLA.0000000000005476. Epub 2022 Jul 6. PMID: 36036990; PMCID: PMC9259047. Go to original source... Go to PubMed...
  38. Shah A, Palmer AJR, Klein AA. Strategies to minimize intraoperative blood loss during major surgery. Br J Surg. 2020 Jan;107(2):e26-e38. doi: 10.1002/bjs.11393. PMID: 31903592. Go to original source... Go to PubMed...
  39. Ševčíková S, Durila M, Vymazal T. Vliv infuzních roztoků na krevní srážlivost. Anest intenziv Med. 2018;29(5):258-264.
  40. Jonáš J, Durila M, Blahýnková M, Vymazal T. Využití rotační tromboelastometrie v perioperační medicíně a její porovnání se standardními koagulačními testy. Anest intenziv Med. 2020;31(5):238-245. Go to original source...
  41. Porter SB, White LJ, Osagiede O, Robards CB, Spaulding AC. Tranexamic Acid Administration Is Not Associated With an Increase in Complications in High­‑Risk Patients Undergoing Primary Total Knee or Total Hip Arthroplasty: A Retrospective Case­‑Control Study of 38,220 Patients. J Arthroplasty. 2020 Jan;35(1):45-51.e3. doi: 10.1016/j.arth.2019. 08. 015. Epub 2019 Aug 17. PMID: 31522854. Go to original source...
  42. Lošťák J, Gallo J, Večeřa M, Špička J, Langová K. Lokální aplikace kyseliny tranexamové u TEP kyčle snižuje krevní ztráty a spotřebu krevních transfuzí [Local Application of Tranexamic Acid in Total Hip Arthroplasty Decreases Blood Loss and Consumption of Blood Transfusion]. Acta Chir Orthop Traumatol Cech. 2017;84(4):254-262. Czech. PMID: 28933328 Go to original source...
  43. Mohinani A, Patel S, Tan V, Kartika T, Olson S, DeLoughery TG, Shatzel J. Desmopressin as a hemostatic and blood sparing agent in bleeding disorders. Eur J Haematol. 2023 May;110(5):470-479. doi: 10.1111/ejh.13930. Epub 2023 Feb 12. PMID: 36656570; PMCID: PMC10073345. Go to original source... Go to PubMed...
  44. Kandane­‑Rathnayake RK, Isbister JP, Zatta AJ, Aoki NJ, Cameron P, Phillips LE; Australian and New Zealand Haemostasis Registry Steering Committee. Use of recombinant activated factor VII in Jehovah's Witness patients with critical bleeding. ANZ J Surg. 2013 Mar;83(3):155-60. doi: 10.1111/j.1445-2197.2012.06285.x. Epub 2012 Oct 4. PMID: 23035873. Go to original source... Go to PubMed...
  45. Fischer DP, Zacharowski KD, Meybohm P. Savoring every drop - vampire or mosquito? Crit Care. 2014 May 21;18(3):306. doi: 10.1186/cc13884. PMID: 25032998; PMCID: PMC4056661. Go to original source... Go to PubMed...
  46. Muñoz M, Acheson AG, Bisbe E, Butcher A, Gómez­‑Ramírez S, Khalafallah AA, et al. An international consensus statement on the management of postoperative anaemia after major surgical procedures. Anaesthesia. 2018 Nov;73(11):1418-1431. doi: 10.1111/anae.14358. Epub 2018 Jul 31. PMID: 30062700; PMCID: PMC6686161. Go to original source... Go to PubMed...
  47. Bolliger D, Erb JM, Tanaka KA. Caring for Jehovah's Witness Patients Undergoing Complex Cardiac Surgery. J Cardiothorac Vasc Anesth. 2023 Apr;37(4):519-521. doi: 10.1053/j.jvca.2022. 12. 029. Epub 2023 Jan 5. PMID: 36681527. Go to original source...
  48. Blatný J, Bláha J, Cvachovec K, Černý V, Firment J, Kubisz P, et al. Diagnostika a léčba život ohrožujícího krvácení u dospělých pacientů v intenzivní a perioperační péči. Česko­‑slovenský mezioborový doporučený postup. Anest intenziv Med. 2017;28(4):263-269.
  49. Rossaint R, Afshari A, Bouillon B, Cerny V, Cimpoesu D, Curry N, et al. The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Crit Care. 2023 Mar 1;27(1):80. doi: 10.1186/s13054-023-04327-7. PMID: 36859355; PMCID: PMC9977110. Go to original source... Go to PubMed...
  50. Chang R, Kerby JD, Kalkwarf KJ, Van Belle G, Fox EE, Cotton BA, et al; PROPPR Study Group. Earlier time to hemostasis is associated with decreased mortality and rate of complications: Results from the Pragmatic Randomized Optimal Platelet and Plasma Ratio trial. J Trauma Acute Care Surg. 2019 Aug;87(2):342-349. doi: 10.1097/TA.0000000000002263. PMID: 31349348; PMCID: PMC6771437. Go to original source... Go to PubMed...
  51. Lilienstein JT, Davis JW, Kochubey M, Garcia L, Kaups KL, Sue LP, Dirks RC. Does autotransfusion from a contaminated trauma laparotomy field increase the risk of complications? Am J Surg. 2022 May;223(5):988-992. doi: 10.1016/j.amjsurg.2021. 10. 006. Epub 2021 Oct 11. PMID: 34657721. Go to original source...
  52. Waters JH. Cell salvage in trauma. Curr Opin Anaesthesiol. 2021 Aug 1;34(4):503-506. doi: 10.1097/ACO.0000000000001014. PMID: 34074882. Go to original source... Go to PubMed...
  53. Casu S. Simplified treatment algorithm for the management of trauma­‑induced hemorrhage without viscoelastic testing. Trauma Surg Acute Care Open. 2021 Jul 16;6(1):e000779. doi: 10.1136/tsaco-2021-000779. PMID: 34337159; PMCID: PMC8287615. Go to original source... Go to PubMed...
  54. Patel PA, Wyrobek JA, Butwick AJ, Pivalizza EG, Hare GMT, Mazer CD, Goobie SM. Update on Applications and Limitations of Perioperative Tranexamic Acid. Anesth Analg. 2022 Sep 1;135(3):460-473. doi: 10.1213/ANE.0000000000006039. Epub 2022 Aug 17. PMID: 35977357. Go to original source... Go to PubMed...
  55. Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger T, Kranke P, et al. Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta­‑analysis, and Meta­‑regression. JAMA Surg. 2021 Apr 14;156(6):e210884. doi: 10.1001/jamasurg.2021.0884. Epub ahead of print. PMID: 33851983; PMCID: PMC8047805. Go to original source... Go to PubMed...
  56. Leal­‑Noval SR, Muñoz M, Asuero M, Contreras E, García­‑Erce JA, Llau JV, et al; Spanish Expert Panel on Alternatives to Allogeneic Blood Transfusion. Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the "Seville Document". Blood Transfus. 2013 Oct;11(4):585-610. doi: 10.2450/2013.0029-13. Epub 2013 Jun 17. PMID: 23867181; PMCID: PMC3827405. Go to original source... Go to PubMed...
  57. Blatný J. Krvácení a jeho léčba - (nejen) hematologický problém. Interní Med. 2009;11(3):120-122.
  58. Beverina I, Ranzin, M. A synchronized approach between emergency department and anemia clinic to intravenous iron treatment for very severe (HbPosluszny JA Jr, Napolitano LM. How do we treat life­‑threatening anemia in a Jehovah's Witness patient? Transfusion. 2014 Dec;54(12):3026-34. doi: 10.1111/trf.12888. Epub 2014 Oct 21. PMID: 25330835. Go to original source... Go to PubMed...
  59. Olaussen A, Bade­‑Boon J, Fitzgerald MC, Mitra B. Management of injured patients who were Jehovah's Witnesses, where blood transfusion may not be an option: a retrospective review. Vox Sang. 2018 Apr;113(3):283-289. doi: 10.1111/vox.12637. Epub 2018 Feb 2. PMID: 29392737. Go to original source... Go to PubMed...
  60. Shander A, Javidroozi M, Gianatiempo C, Gandhi N, Lui J, Califano F, et al. Outcomes of Protocol­‑Driven Care of Critically Ill Severely Anemic Patients for Whom Blood Transfusion Is Not an Option. Crit Care Med. 2016 Jun;44(6):1109-15. doi: 10.1097/CCM.0000000000001599. PMID: 26807684. Go to original source... Go to PubMed...
  61. Sanchez IF, Lee HY, Lee JM. Successfully Managing Severe Anemia in a Trauma Patient Who Refused Blood Transfusion: A Case Report. Am J Case Rep. 2023 Oct 12;24:e940326. doi: 10.12659/AJCR.940326. PMID: 37822074; PMCID: PMC10584198. Go to original source... Go to PubMed...
  62. Ray JG, Davidson A, Berger H, Dayan N, Park AL. Haemoglobin levels in early pregnancy and severe maternal morbidity: population­‑based cohort study. BJOG. 2020 Aug;127(9):1154-1164. doi: 10.1111/1471-0528.16216. Epub 2020 Apr 6. PMID: 32175668. Go to original source... Go to PubMed...
  63. Pařízek A, Binder T, Bláha J, a kol. Diagnostika a léčba peripartálního život ohrožujícího krvácení. Česko­‑slovenský mezioborový konsenzus. Čes Gynek. 2018;83(2):151-158.
  64. Nguyen TN, Boyd ME. Bloodless Management of Postpartum Hemorrhage and Jehovah's Witnesses. J Obstet Gynaecol Can. 2019 Jun;41(6):743-744. doi: 10.1016/j.jogc.2019. 03. 020. PMID: 31126430. Go to original source...
  65. Matsunaga S, Takai Y, Seki H. Fibrinogen for the management of critical obstetric hemorrhage. J Obstet Gynaecol Res. 2019 Jan;45(1):13-21. doi: 10.1111/jog.13788. Epub 2018 Aug 28. PMID: 30155944; PMCID: PMC6585962. Go to original source... Go to PubMed...
  66. WOMAN Trial Collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post­‑partum haemorrhage (WOMAN): an international, randomised, double­‑blind, placebo­‑controlled trial. Lancet. 2017 May 27;389(10084):2105-2116. doi: 10.1016/S0140-6736(17)30638-4. Epub 2017 Apr 26. Erratum in: Lancet. 2017 May 27;389(10084):2104. PMID: 28456509; PMCID: PMC5446563. Go to original source... Go to PubMed...
  67. Sentilhes L, Sénat MV, Le Lous M, Winer N, Rozenberg P, Kayem G, et al; Groupe de Recherche en Obstétrique et Gynécologie. Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery. N Engl J Med. 2021 Apr 29;384(17):1623-1634. doi: 10.1056/NEJMoa2028788. PMID: 33913639. Go to original source... Go to PubMed...
  68. Hofer S, Blaha J, Collins PW, Ducloy­‑Bouthors AS, Guasch E, Labate F, et al. Haemostatic support in postpartum haemorrhage: A review of the literature and expert opinion. Eur J Anaesthesiol. 2023 Jan 1;40(1):29-38. doi: 10.1097/EJA.0000000000001744. Epub 2022 Sep 22. PMID: 36131564; PMCID: PMC9794135. Go to original source... Go to PubMed...
  69. Surbek D, Vial Y, Girard T, Breymann C, Bencaiova GA, Baud D, et al. Patient blood management (PBM) in pregnancy and childbirth: literature review and expert opinion. Arch Gynecol Obstet. 2020 Feb;301(2):627-641. doi: 10.1007/s00404-019-05374-8. Epub 2019 Nov 14. PMID: 31728665; PMCID: PMC7033066. Go to original source... Go to PubMed...
  70. Liu Y, Li X, Che X, Zhao G, Xu M. Intraoperative cell salvage for obstetrics: a prospective randomized controlled clinical trial. BMC Pregnancy Childbirth. 2020 Aug 7;20(1):452. doi: 10.1186/s12884-020-03138-w. PMID: 32767971; PMCID: PMC7412832. Go to original source... Go to PubMed...
  71. Sullivan IJ, Ralph CJ. Obstetric intra­‑operative cell salvage: a review of an established cell salvage service with 1170 re­‑infused cases. Anaesthesia. 2019 Aug;74(8):976-983. doi: 10.1111/anae.14630. Epub 2019 Mar 25. PMID: 30912123. Go to original source... Go to PubMed...
  72. Zeybek B, Childress AM, Kilic GS, Phelps JY, Pacheco LD, Carter MA, Borahay MA. Management of the Jehovah's Witness in Obstetrics and Gynecology: A Comprehensive Medical, Ethical, and Legal Approach. Obstet Gynecol Surv. 2016 Aug;71(8):488-500. doi: 10.1097/OGX.0000000000000343. PMID: 27526872; PMCID: PMC4991563. Go to original source... Go to PubMed...
  73. Muñoz M, Stensballe J, Ducloy­‑Bouthors AS, Bonnet MP, De Robertis E, Fornet I, et al. Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement. Blood Transfus. 2019 Mar;17(2):112-136. doi: 10.2450/2019.0245-18. Epub 2019 Feb 6. PMID: 30865585; PMCID: PMC6476742. Go to original source... Go to PubMed...
  74. Roman MA, Abbasciano RG, Pathak S, Oo S, Yusoff S, Wozniak M, Qureshi S, Lai FY, Kumar T, Richards T, Yao G, Estcourt L, Murphy GJ. Patient blood management interventions do not lead to important clinical benefits or cost­‑effectiveness for major surgery: a network meta­‑analysis. Br J Anaesth. 2021 Jan;126(1):149-156. doi: 10.1016/j.bja.2020. 04. 087. Epub 2020 Jun 30. PMID: 32620259; PMCID: PMC7844348. Go to original source...
  75. Faraoni D, Gross I, Shander A. Network meta­‑analysis of isolated patient blood management interventions leads to uncertain interpretation. Comment on Br J Anaesth. 2020; Br J Anaesth. 2021 Jan;126(1):e1-e2. doi: 10.1016/j.bja.2020. 07. 021. Epub 2020 Aug 21. PMID: 32838981. Go to original source...
  76. Trentino KM, Spahn DR, Mace HS, Gombotz H, Hofmann A. Is patient blood management cost­‑effective? Comment on Br J Anaesth 2020. Br J Anaesth. 2021 Jan;126(1):e7-e9. doi: 10.1016/j.bja.2020. 09. 003. Epub 2020 Sep 26. PMID: 32988601. Go to original source...
  77. Javidroozi M, Hardy JF, Ozawa S. Patient blood management interventions lead to important benefits for major surgery. Comment on Br J Anaesth 2020. Br J Anaesth. 2021 Jan;126(1):e4-e5. doi: 10.1016/j.bja.2020. 10. 009. Epub 2020 Nov 10. PMID: 33187634. Go to original source...




Anesteziologie a intenzivní medicína

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.